Brain Derived Neurotrophic Factor and Alzheimer’s disease
Dec 19, 2025
The pathology of Alzheimer’s disease (AD) involves the accumulation of amyloid beta (AB) and tau proteins in the brain. These protein aggregates clump together and create neuroinflammation, synaptic changes and neuronal death which can contribute to neurodegeneration and cognitive decline symptoms.
Brain Derived Neurotrophic Factor (BDNF) is a well-researched growth factor produced naturally in the brain. It has been described as “Miracle Grow for the brain” due to its ability to support synaptic firing and plasticity, decrease the expression and accumulation of tau and AB and protect neuron cells from premature cell death.
Lower measured levels of BDNF have been found in individuals diagnosed with AD and related dementia pathologies. Decreased BDNF levels have been associated with declining cognition, impaired learning and memory and abnormal changes to mood-related behaviors.
BDNF has become a therapeutic target in combatting AD and other causes of dementia. Increasing BDNF levels in the brain may lead to improved clinical outcomes.
BDNF supplements are available, but evidence is mixed and results have found to be modest for many over-the-counter products. More human studies are necessary to demonstrate consistent positive findings.
Exercise and nutrition are considered to be more reliable boosters of BDNF. A study where participants with a clinical diagnosis of mild to moderate AD engaged in 60 minutes of exercise three times a week showed them to significantly increase their plasma levels of BDNF after 12 weeks as well as their executive and attentional functions, mobility, gait speed and balance.
Foods high in polyphenols, antioxidants and omega 3 fatty acids have been found to support BDNF production and signaling. These foods also tend to be anti-inflammatory and optimize insulin/blood glucose regulation which also supports brain health.
Oral BDNF may become a valuable therapeutic option in the future, but research indicates that exercise and nutritional strategies are excellent modifiable factors which can improve BDNF as well as many other advantageous health targets. Exercising at least three times a week and eating plenty of fish/sea food and colorful plants is a great place to start in improving cognitive health.
Source:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8796548/
Download the 7 Pillars to a Thriving Mind
A comprehensive ebook guide with journaling prompts by Dr. Kaas to help you protect, preserve and optimize your brain health for a more functional present and future.
We hate SPAM. We will never sell your information, for any reason.
